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Climate Change Institute


Matthew Kruger

PhD Student in GSBSE and IGERT A2C2 Fellow

Matthew Kruger

Contact Information

Email/web:
matthew.kruger@maine.edu
Download CV

Address:
217 Hitchner Hall
Orono, ME  04469

Biosketch

I am a 2nd year PhD student in the Biomedical Sciences program (GSBSE) working with Dr. Roger Sher. I graduated with my Bachelor’s degree in Biology from Washington State University in 2012, where I performed undergraduate research in Dr. Steve Sylvester’s lab for 1 year. I also received my Master's degree in Zoology from Washington State University in 2015 where I studied chemically-induced hearing loss.

Research interests

My current graduate work focuses on studying environmentally-induced amyotrophic lateral sclerosis (ALS), a neurodegenerative disease that leads to the loss of muscle control and ultimately death. Chronic exposure to the environmental toxin, β-Methylamino-L-alanine (BMAA), has been associated with an increase prevalence of ALS. However, the mechanism of how chronic BMAA exposure increases the prevalence of ALS is unknown. Zebrafish are an excellent model for parsing out the link between environmental toxins and ALS due to their large-scale pharmacological manipulation and rapid assessment. I am passionate about increasing our understanding of how different environmental toxics increase the prevalence of ALS in order to identify novel molecular targets to block the progression of ALS in humans.

I am also interested in understanding how increasing global temperatures as a result of abrupt climate change (ACC) may be affecting the concentration of BMAA in public drinking water sources; harmful algal blooms (HAB) produced by cyanobacteria are a major source of BMAA. Furthermore, rising global temperatures will increase the presence of HAB, resulting in an increase in BMAA production. A better understanding of how ACC affects public water sources will provide government and corporations with the knowledge to create or modify policies to slow ACC and algal bloom expansion, and reduce the impact of algae-induced ALS, to help sustain both local and global public drinking water sources over the next decade.

Publications

  • Kruger M, Boney R, Ordoobadi A, Sommers T, Trapani J, et al. (2016) Natural Bizbenzoquinoline Derivatives Protect Zebrafish Lateral Line Sensory Hair Cells from Aminoglycoside Toxicity. Front Cell Neurosci 10.

    For more information: Read abstract

  • Hayashi L, Sheth M, Young A, Kruger M, Wayman GA, Coffin AB (2015) The effect of the aquatic contaminants bisphenol-A and PCB-95 on the zebrafish lateral line. Neurotoxicology 46:125–136.

    For more information: Read abstract

Education

B.S. Biology, Washington State University, 2012; M.S. Zoology, Washington State University, 2015

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